The Benefits of Bio-Synergy® Beta-Performance™ HMB: Backed by Science Since the 1990s
If you’re looking for faster recovery, reduced muscle breakdown, and improved strength gains, you’ve probably heard of HMB (beta-hydroxy beta-methylbutyrate). But did you know that Bio-Synergy® was one of the first brands in the world to research and develop HMB supplements — way back in the 1990s?
In this post, we’ll share:
What HMB is and how it works
Highlights from our pioneering 1990s University of London study
The latest 2022 research in professional athletes
Why Bio-Synergy® Beta-Performance™ HMB still leads the field today
What is HMB and Why Do Athletes Use It?
HMB is a metabolite of the essential amino acid leucine, known for its role in muscle protein synthesis. Research shows HMB helps:
Reduce muscle protein breakdown during intense training or calorie restriction
Support muscle repair by activating mTOR and IGF-1 pathways
Lower markers of muscle damage like creatine kinase (CK) and lactate dehydrogenase (LDH)
Improve recovery time and training consistency
Our Groundbreaking 1990s HMB Research
In the late 1990s, Bio-Synergy® worked with the University of London and Royal Free Hospital to study calcium HMB supplementation in resistance-trained athletes.
Study details:
Participants: 20 experienced male athletes
Dosages: 1.35g or 2.69g/day of calcium HMB (Bio-Synergy® Beta-Performance™) for 14 days
Design: Double-blind, placebo-controlled trial
Key findings:
Significant increases in serum HMB (p=0.009) and urinary HMB (p=0.03) — proving strong bioavailability
Lower CK levels in higher-dose group — suggesting reduced muscle damage
No negative changes to blood markers or metabolic health
Athletes reported faster recovery and reduced soreness
Modern Science Confirms the Benefits
Fast forward to 2022, and a published study on professional football players found that short-term HMB free acid (HMB-FA) supplementation significantly reduced CK and LDH after a simulated match.
Highlights from the 2022 study:
Reduced muscle injury indices — better recovery potential
Mechanisms include increased satellite cell activation, muscle hypertrophy, and reduced protein breakdown
Effective for both trained and untrained individuals, though elite athletes see best results over longer cycles
Why Choose Bio-Synergy® Beta-Performance™ HMB?
Bio-Synergy® has been at the forefront of HMB research and supplementation for over 25 years. Our Beta-Performance™ HMB formula is designed to:
Protect lean muscle mass during training and calorie deficits
Enhance strength and power gains alongside resistance training
Improve training frequency by reducing DOMS
Support safe, long-term use with no adverse effects on metabolic health
Who Can Benefit from HMB Supplementation?
HMB is ideal for:
Strength and power athletes
Footballers, rugby players, and other team-sport athletes
Endurance athletes during high-intensity phases
Those recovering from injury or immobilization
Older adults maintaining muscle mass
The Bio-Synergy® Advantage: Proven Before It Was Popular
When you choose Bio-Synergy® Beta-Performance™ HMB, you’re getting more than just a supplement — you’re getting decades of proven results. We helped introduce HMB to the sports nutrition world, and we’re still leading the way in quality, purity, and scientific backing.
References:
Hughes S., Sanford E., et al. (1999). Biochemical and haematological effects of β-HMB supplementation. University of London & Royal Free Hospital.
Rezaeimanesh D., et al. (2022). Response of muscle damage indices to short-term supplementation of HMB-FA in professional soccer players. doi:10.47750/pnr.2022.13.01.013
